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Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design by Lennart Bunch; Povl Krogsgaard-Larsen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract (__S__)‐Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system, activating the plethora of glutamate receptors (GluRs). In broad lines, the GluRs are divided into two major classes: the ionotropic Glu receptors (iGluRs) and the metabotropic Glu receptors (mGluRs). Within the iGluRs, five subtypes (KA1, KA2, iGluR5‐7) show high affinity and express full agonist activity upon binding of the naturally occurring amino acid kainic acid (KA). Thus these receptors have been named the KA receptors. This review describes all—to our knowledge—published KA receptor agonists. In total, over 100 compounds are described by means of chemical structure and available pharmacological data. With this perspective review, it is our intention to ignite and stimulate inspiration for future design and synthesis of novel subtype selective KA receptor agonists. © 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 1, 3–28, 2009

Who reads Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design?

Author

Lennart Bunch; Povl Krogsgaard-Larsen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0198-6325)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)