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Activation of Immobility-related Hippocampal Theta by Cholinergic Septohippocampal Neurons During Vestibular Stimulation by Siew Kian Tai; Jingyi Ma; Klaus-Peter Ossenkopp; L. Stan Leung is a Neuroscience article available to read on EtoBox.

What is Activation of Immobility-related Hippocampal Theta by Cholinergic Septohippocampal Neurons During Vestibular Stimulation about?

## Abstract The vestibular system has been suggested to participate in spatial navigation, a function ascribed to the hippocampus. Vestibular stimulation during spatial navigation activates a hippocampal theta rhythm (4–10 Hz), which may enhance spatial processing and motor response. We hypothesize that a cholinergic, atropine‐sensitive theta is generated during passive whole‐body rotation in freely behaving rats. Hippocampal EEGs were recorded by implanted electrodes in CA1 while rats were rotated on a vertical axis, for a minute or longer, at different angular velocities. Rotation induced a continuous hippocampal theta rhythm while the rat was immobile, in both light and dark conditions. Theta peak frequency showed a significant increase during high (50–70 rpm) as compared with a lower (20–49 rpm) rotational velocity. Rotation‐induced theta was abolished by muscarinic receptor antagonist atropine sulfate (50 mg/kg i.p.) but not by atropine methyl nitrate (50 mg/kg i.p.), which did not pass the blood‐brain barrier. Theta was attenuated in rats in which cholinergic neurons in the medial septum (MS) were lesioned with 192 IgG‐saporin (0.14 μg in 0.4 μl), as confirmed by depletion of

Who reads Activation of Immobility-related Hippocampal Theta by Cholinergic Septohippocampal Neurons During Vestibular Stimulation?

Author

Siew Kian Tai; Jingyi Ma; Klaus-Peter Ossenkopp; L. Stan Leung

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)