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Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for posterior eye disease therapeutics: Virtual screening, construction and comparison by Tingting Zhang; Xinyi Jiao; Xingru Peng; Haitao Wang; Yadan Zou; Yanyu Xiao; Rui Liu; Zheng Li is a Chemical Engineering article available to read on EtoBox.
What is Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for posterior eye disease therapeutics: Virtual screening, construction and comparison about?
Local deliver medication in a non-invasive pattern and attaining a long-term sustained release at ocular regions to minimize side effects is fascinating for treatment and precision medicine, but its rational design remains a challenge. The aim of this study was to analyze the effect of different delivery strategies on drug bioavailability in the posterior segment of the eye. In this study, the results of molecular dynamics (MD) revealed that quercetin (QUE) and curcumin (CUR) have shown superior affinity and tighter binding capacity for the active site of vascular endothelial growth factor (VEGF). Then, developing and comparing lipid-based nanoemulsion (NE) and polymer-based nanomicelles (NM) were modified with novel mPEG-CS to achieve adequate targeting and retention. The results of in vitro biological properties showed that nano-preparations could be successfully absorbed by cells. The result of in vivo pharmacokinetics revealed that two kinds of nano-preparations could prominently enhance the ocular bioavailability of QUE and CUR to different degrees and have a certain sustained-release effect. More importantly, the results showed that the particle size of NE was smaller than th
Who reads Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for posterior eye disease therapeutics: Virtual screening, construction and comparison?
It is typically read by researchers, students, and practitioners in Chemical Engineering.
- Author
- Tingting Zhang; Xinyi Jiao; Xingru Peng; Haitao Wang; Yadan Zou; Yanyu Xiao; Rui Liu; Zheng Li
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Chemical Engineering (Physical Sciences)