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Can I read Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study on EtoBox?
Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study by Paul Glue; Shona Neehoff; Amandine Sabadel; Lucy Broughton; Martin Le Nedelec; Shabah Shadli; Neil McNaughton; Natalie J Medlicott is a Neuroscience article available to read on EtoBox.
What is Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study about?
## Background: We previously reported that ketamine has anxiolytic effects in patients with treatment-resistant generalized anxiety and social anxiety disorders. ## Aims: The purpose of this study was to replicate our earlier report about ketamine‘s anxiolytic activity, using a more robust study design. ## Methods: This was a double-blind, psychoactive-controlled ascending dose study in 12 patients with treatment-resistant generalized anxiety and social anxiety disorders who were not currently depressed. Ascending doses of ketamine (0.25, 0.5, 1 mg/kg) were administered at weekly intervals, and midazolam 0.01 mg/kg, the control, was randomly inserted into the ketamine dose sequence. Assessments included ratings of anxiety and dissociation, safety and tolerability, and blood samples for ketamine pharmacokinetics and BDNF concentrations. ## Results: Improvements in anxiety ratings occurred within an hour of ketamine dosing, and persisted for up to 1 week. A dose-response profile was noted for anxiolytic effects, dissociative side effects, and changes in blood pressure and heart rate after ketamine dosing. Midazolam had minor brief effects on anxiety ratings. Ketamine was safe and wel
Who reads Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Paul Glue; Shona Neehoff; Amandine Sabadel; Lucy Broughton; Martin Le Nedelec; Shabah Shadli; Neil McNaughton; Natalie J Medlicott
- Publisher
- SAGE Publications
- Published
- 2019
- Language
- EN
- Field
- Neuroscience (Life Sciences)