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Paracetamol in Therapeutic Dosages and Acute Liver Injury: Causality Assessment in a Prospective Case Series by Mònica Sabaté; Luisa Ibáñez; Eulàlia Pérez; Xavier Vidal; Maria Buti; Xavier Xiol; Antoni Mas; Carlos Guarner; Montserrat Forné; Ricard Solà; José Castellote; Joaquim Rigau; Joan-Ramon Laporte is a Medicine article available to read on EtoBox.
What is Paracetamol in Therapeutic Dosages and Acute Liver Injury: Causality Assessment in a Prospective Case Series about?
## Background Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case. ## Methods Based on the evaluation of prospectively gathered cases of ALI with detailed clinical information, thirty-two cases of ALI in non-alcoholic patients exposed to therapeutic doses of paracetamol were identified. Two authors assessed all drug exposures by using the CIOMS/RUCAM scale. Each case was classified into one of five categories based on the causality score for paracetamol. ## Results In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in
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- Author
- Mònica Sabaté; Luisa Ibáñez; Eulàlia Pérez; Xavier Vidal; Maria Buti; Xavier Xiol; Antoni Mas; Carlos Guarner; Montserrat Forné; Ricard Solà; José Castellote; Joaquim Rigau; Joan-Ramon Laporte
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-230X)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)