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Continuous Counter-current Extraction on an Industrial Sample Using Dual-flow Counter-current Chromatography by Remco van den Heuvel; Ben Mathews; Stephane Dubant; Ian Sutherland is a Chemistry article available to read on EtoBox.

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a b s t r a c t Both batch and continuous separations were performed on an industrial liquor using a specially built continuous counter-current extraction centrifuge. Changing the flow regime for different batch separations showed that the elution of components from the respective ends of the coil depends on the flow rates of both upper and lower phases. It was shown that, within the scope of the study, the elution of the components was not affected by the concentration of the injected reaction liquor and more importantly that continuous processing with a counter-current chromatography centrifuge was feasible. This research represents an important step forward in making continuous counter-current chromatography (or true moving bed chromatography) accessible for the pharmaceutical industry.

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Author

Remco van den Heuvel; Ben Mathews; Stephane Dubant; Ian Sutherland

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)