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Quality of packed red blood cells and platelet concentrates collected by multicomponent collection using the MCS plus device by G.C. Leitner; P. Jilma‐Stohlawetz; G. Stiegler; G. Weigel; M. Horvath; A. Tanzmann; P. Höcker; M.B. Fischer is a Medicine article available to read on EtoBox.

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## Abstract The demand for blood components is constantly increasing, while the exclusion criteria for donors are strengthened in order to reach maximal safety for donors and patients. To counterbalance reduced availability of volunteers, multicomponent collections (MCC) is an attractive approach to produce more than one component during a single apheresis procedure from one donor, such as packed red blood cells (PRBCs) and platelet concentrates (PCs). Further, the exposures of patients to a limited number of donors reduces the possibility of alloimmunization and transfusion‐related diseases. We measured the quality of PRBCs and PCs obtained by MCC, using the MCS+ device with the LDPRBC program, Revision B, and compared them with the quality of manually collected PRBCs and PCs collected with the Revision C2 of the MCS+. We found higher pH levels and lower hemolysis assessed by means of fHb and K+ in the supernatant of PRBCs over the whole storage period of 42 days in MCC‐derived PRBCs. The functional metabolism assessed by intracellular ATP was higher in PRBCs collected by MCC than in manually collected units. Furthermore, PCs obtained during MCC showed an increase in p‐selectin ex

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Author

G.C. Leitner; P. Jilma‐Stohlawetz; G. Stiegler; G. Weigel; M. Horvath; A. Tanzmann; P. Höcker; M.B. Fischer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0733-2459)

Published

2003

Language

EN

Field

Medicine (Health Sciences)