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Forecasting the Growth of Multicell Tumour Spheroids: Implications for the Dynamic Growth of Solid Tumours by R. Chignola; A. Schenetti; G. Andrighetto; E. Chiesa; R. Foroni; S. Sartoris; G. Tridente; D. Liberati is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Forecasting the Growth of Multicell Tumour Spheroids: Implications for the Dynamic Growth of Solid Tumours about?
The growth dynamics of multicell tumour spheroids (MTS) were analysed by means of mathematical techniques derived from signal processing theory. Volume __vs.__ time trajectories of individual spheroids were fitted with the Gompertz growth equation and the residuals (i.e. experimental volume determinations minus calculated values by fitting) were analysed by fast fourier transform and power spectrum. Residuals were not randomly distributed around calculated growth trajectories demonstrating that the Gompertz model partially approximates the growth kinetics of three‐dimensional tumour cell aggregates. Power spectra decreased with increasing frequency following a 1/f^δ^ power‐law. Our findings suggest the existence of a source of ‘internal’ variability driving the time‐evolution of MTS growth. Based on these observations, a new stochastic Gompertzian‐like mathematical model was developed which allowed us to forecast the growth of MTS. In this model, white noise is additively superimposed to the trend described by the Gompertz growth equation and integrated to mimic the observed intrinsic variability of MTS growth. A correlation was found between the intensity of the added noise and th
Who reads Forecasting the Growth of Multicell Tumour Spheroids: Implications for the Dynamic Growth of Solid Tumours?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- R. Chignola; A. Schenetti; G. Andrighetto; E. Chiesa; R. Foroni; S. Sartoris; G. Tridente; D. Liberati
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0960-7722)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)