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Low-dose Theophylline in Childhood Asthma: a Placebo-controlled, Double-blind Study by Sandra Suessmuth; Joachim Freihorst; Monika Gappa is a Medicine article available to read on EtoBox.

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Regular anti‐inflammatory treatment is essential in treating persistent asthma. Most commonly, inhaled corticosteroids (ICS) are used. However, especially in children, there is concern about the long‐term safety of ICS such that doses should be kept to a minimum. The use of theophylline has decreased because of frequent side‐effects in therapeutic doses. In adults, there have been reports about an immunomodulatory effect of low‐dose theophylline. To study the clinical and immunomodulatory effect in children, 36 patients (mean age 12.5 SD 2.4 years) with moderate, persistent asthma on regular ICS were recruited into a placebo‐controlled, double‐blind study. After a 6‐week run‐in period, patients received either theophylline 10 mg/kg bodyweight or placebo for 12 weeks. Diary cards, lung function, peripheral blood lymphocyte subpopulations and serum eosinophil cationic protein (sECP) were assessed. In the treatment group, mean serum theophylline was 7.1 mg/l. There was no change in symptoms or use of rescue medication. Mean (SD) peak expiratory flow (PEF) increased from 86% (24) to 95% (18) predicted. sECP decreased from 43.2 μg/l (32.5) to 26.5 μg/l (16.9) (p = 0.02). Lymphocyte subp

Who reads Low-dose Theophylline in Childhood Asthma: a Placebo-controlled, Double-blind Study?

Author

Sandra Suessmuth; Joachim Freihorst; Monika Gappa

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0905-6157)

Published

2003

Language

EN

Field

Medicine (Health Sciences)