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The Extracellular Matrix as a Multitasking Player in Disease by Achilleas D. Theocharis; Dimitra Manou; Nikos K. Karamanos is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Extracellular Matrix as a Multitasking Player in Disease about?

Extracellular matrices (ECMs) are highly specialized and dynamic three‐dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar components, such as collagens, fibronectin, and elastin, and non‐fibrillar molecules as proteoglycans, hyaluronan, and glycoproteins including matricellular proteins. These macromolecular components are interconnected forming complex networks that actively communicate with cells through binding to cell surface receptors and/or matrix effectors. ECMs exert diverse roles, either providing tissues with structural integrity and mechanical properties essential for tissue functions or regulating cell phenotype and functions to maintain tissue homeostasis. ECM molecular composition and structure vary among tissues, and is markedly modified during normal tissue repair as well as during the progression of various diseases. Actually, abnormal ECM remodeling occurring in pathologic circumstances drives disease progression by regulating cell–matrix interactions. The importance of matrix molecules to normal tissue functions is also highlighted by mutations in matrix genes that give rise to genetic disorders with diverse c

Who reads The Extracellular Matrix as a Multitasking Player in Disease?

Author

Achilleas D. Theocharis; Dimitra Manou; Nikos K. Karamanos

Publisher

Wiley

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)