Opening book details…
Can I read Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones on EtoBox?
Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones by Ulrich T. Mueller-Westerhoff; Ming Zhou is a Chemistry article available to read on EtoBox.
What is Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones about?
The reaction of an equimolar mixture ofN,"-dialkylethylenediamines and diethyl oxalate in diethyl ether or 2-propanol leads to 1,4-dialkylpiperazine-2,3-diones. As cyclic and nearly planar tetraalkyl oxamides, these compounds are able to react with 2 equiv of organolithium or Grignard compounds to form, after hydrolysis, symmetrically substituted a-diones in excellent yields. The sequential addition of 1 equiv each of two different organolithium compounds affords unsymmetrically substituted a-diones when the more soluble longer chain dialkyl derivatives of piperazine-2,3-dione are employed. The dialkylethylenediamines can conveniently be recovered and recycled to the 1,4dialkylpiperazine-2,3-diones in good yields.
Who reads Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ulrich T. Mueller-Westerhoff; Ming Zhou
- Publisher
- American Chemical Society (ACS)
- Published
- 1994
- Language
- EN
- Field
- Chemistry (Physical Sciences)