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Measurement of Reactive Oxygen Species in Cardiovascular Studies by Sergey Dikalov; Kathy K. Griendling; David G. Harrison is a Medicine article available to read on EtoBox.

What is Measurement of Reactive Oxygen Species in Cardiovascular Studies about?

everal mammalian enzymes are capable of transferring electrons to molecular oxygen, sequentially forming the 1 electron-reduction product superoxide (O 2 1⁄7Ϫ ) and the 2 electron-reduction product hydrogen peroxide (H 2 O 2 ). These serve as progenitors for other reactive oxygen species (ROS), including peroxynitrite (ONOO Ϫ ), hypochlorous acid, the hydroxyl radical, lipid peroxides, lipid peroxy-radicals, and lipid alkoxyl radicals. Another relevant group of molecules is the reactive nitrogen species, including NO, the nitrogen dioxide radical, and the nitrosonium cation. In the cardiovascular system, the most important enzymes that produce ROS are the Nox-based reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidase, the mitochondrial electron transport system and, under certain circumstances, NO synthase. Conditions such as hypertension, atherosclerosis, hypercholesterolemia, diabetes, and insulin resistance increase either the activity or the expression of these enzymes, leading to elevated ROS production. ROS, in turn, contribute to these disorders. As examples, virtually every aspect of atherosclerotic lesion formation is augmented by oxidativ

Who reads Measurement of Reactive Oxygen Species in Cardiovascular Studies?

Author

Sergey Dikalov; Kathy K. Griendling; David G. Harrison

Publisher

Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0194-911X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)