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Fecal microbiota transplantation for diseases: Therapeutic potential, methodology, risk management in clinical practice 1 1 Introduction 1 2 FMT in gastrointestinal diseases 2 2.1 C. difficile infection 2 2.2 Inflammatory bowel disease 3 2.2.1 Ulcerative colitis 3 2.2.2 Crohn's disease 5 3 FMT in metabolic disorders 7 3.1 Obesity 7 3.2 Liver metabolic disease 7 4 FMT and neurological diseases 8 5 Adjunctive role of FMT in treating malignant tumors 8 6 Methodology and risk management of FMT in clinical application 9 6.1 Donor sources and delivery methods for FMT 9 6.2 Reported adverse reactions and possible causes 9 6.3 Current risk management system 10 7 Summary and outlook 10 CRediT authorship contribution statement 11 Declaration of competing interest 11 Acknowledgements 11 References 11

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EN

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nonfiction