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Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice by Jinqiang Zhang; Liangyuan Li; Qin Liu; Zhihuang Zhao; Dapeng Su; Chenghong Xiao; Ting Jin; Li Chen; Chunyun Xu; Zili You; Tao Zhou is a Medicine article available to read on EtoBox.
What is Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice about?
Background Regulating the microglial phenotype is an attractive strategy for treating diseases of the central nervous system such as depression and anxiety. Gastrodin can quickly cross the blood-brain barrier and mitigate microglia-mediated inflammation, which widely used to treat a variety of central nervous system diseases associated with microglial dysfunction. However, the molecular mechanism by which gastrodin regulates the functional phenotype of microglia remains unclear. Purpose Since the transcription factor “nuclear factor erythroid 2-related factor 2′′ (Nrf2) is associated with the anti-inflammatory effects of gastrodin, we hypothesized that gastrodin induces Nrf2 expression in microglia and thereby programs an anti-inflammatory phenotype. Study design Male C57BL/6 mice, treated or not with gastrodin, were given lipopolysaccharide (LPS) at 0.25 mg/kg/d for 10 days to induce chronic neuroinflammation. The effects of gastrodin on microglial phenotypes, neuroinflammation and depression- and anxiety-like behaviors were evaluated. In another experiment, animals were treated with Nrf2 inhibitor ML385 throughout the 13-day gastrodin intervention period. Methods The effects of g
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- Author
- Jinqiang Zhang; Liangyuan Li; Qin Liu; Zhihuang Zhao; Dapeng Su; Chenghong Xiao; Ting Jin; Li Chen; Chunyun Xu; Zili You; Tao Zhou
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)