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Tacrine-Ferulic Acid Hybrids for Alzheimer by s2955484 is a document available to read on EtoBox.

This study presents the design and synthesis of five tacrine–ferulic acid hybrids as potential multi-potent anti-Alzheimer drug candidates. The compounds demonstrated improved acetylcholinesterase inhibitory activity compared to tacrine, with one compound (6d) showing reversible non-competitive inhibition for acetylcholinesterase and competitive inhibition for butyrylcholinesterase. Additionally, the hybrids exhibited significant antioxidant properties, indicating their potential in addressing multiple path

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s2955484

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EN