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Can I read Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease on EtoBox?
Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease by Hajime Tokita; Seiyou Murai; Hiroshi Kamitsukasa; Michiyasu Yagura; Hideharu Harada; Akira Hebisawa; Masaharu Takahashi; Hiroaki Okamoto is a Medicine article available to read on EtoBox.
What is Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease about?
The sera of 38 patients with nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH), were tested for TT virus (TTV) DNA by polymerase chain reaction (PCR) using three different primer pairs (UTR PCR, N22 PCR and genotype-1 PCR), and various histological features of the liver biopsy specimens were compared among those who were positive or negative for TTV infection. By UTR PCR which detects all TTV genotypes, TTV DNA was detected in 37 (97%) of the 38 patients. In contrast, N22 PCR which detects primarily TTV genotypes 1 -4, detected TTV DNA in 18 patients (47%). In the liver biopsy specimens, moderate to many acidophilic bodies, moderate to marked focal/ spotty necrosis of hepatocytes and marked stellate, pericellular or perivenular fibrosis were observed significantly more frequently among those who were positive for TTV DNA by N22 PCR, than among those who were negative by N22 PCR. Twelve patients (32%) were positive for TTV genotype 1. Moderate to marked vacuolation of nuclei, moderate to many acidophilic bodies, and moderate to marked focal/spotty necrosis as well as marked stellate, pericellular or perivenular fibrosis were found significantly m
Who reads Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hajime Tokita; Seiyou Murai; Hiroshi Kamitsukasa; Michiyasu Yagura; Hideharu Harada; Akira Hebisawa; Masaharu Takahashi; Hiroaki Okamoto
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier BV; Wiley (ISSN 1386-6346)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)