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Sampling and Storage Conditions Influencing the Measurement of Parathyroid Hormone in Blood Samples: a Systematic Review by Elodie A. Hanon; Catharine M. Sturgeon; Edmund J. Lamb is a Medicine article available to read on EtoBox.

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## Abstract Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of 5511 papers identified, 96 underwent full text review, of which 83 were finally included. At room temperature PTH was stable in ethylenediaminetetraacetic acid (EDTA) preserved whole blood for at least 24 h and in EDTA plasma for at least 48 h after venepuncture. Losses were observed in clotted blood samples after 3 h and in serum after 2 h. At 4°C PTH was more stable in EDTA plasma (at least 72 h) than serum (at least 24 h). Central venous PTH concentrations were higher than peripheral venous concentrations. In the northern hemisphere, PTH concentrations were higher in winter than summer. PTH has a circadian rhythm characterised by a nocturnal acrophase and mid-morning nadir. Data related to frozen storage of PTH (−20°C and −80°C) were limited and contradictory. We recommend that blood samples fo

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Author

Elodie A. Hanon; Catharine M. Sturgeon; Edmund J. Lamb

Publisher

Walter de Gruyter GmbH

Published

2013

Language

EN

Field

Medicine (Health Sciences)