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Eighteen symmetrical bis-Schiff base derivatives of isatin were synthesized and evaluated for their antitumor activity, with compound 3b showing the most potent cytotoxicity against HepG2 cells (IC50 ~ 4.23 mM) and significant tumor growth inhibition in vivo. The study revealed that 3b induced mitosis interference and apoptosis in cancer cells, arresting the cell cycle at the G2/M phase by down-regulating cyclin B1 and cdc 2 expression. Overall, 3b demonstrated stronger antitumor efficacy and fewer side eff

Author

Vighneesh Bakthavachalam

Language

EN