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Evaluation of Renal Oxygenation and Hemodynamics in Patients with Chronic Kidney Disease by Blood Oxygenation Level-dependent Magnetic Resonance Imaging and Intrarenal Doppler Ultrasonography by Jing Yang; Shuohui Yang; Yizeng Xu; Fang Lu; Lan You; Zheng He; Songhua Zhan; Chaoyang Ye; Mengxiao Liu; Caixia Fu; Chen Wang is a Medicine article available to read on EtoBox.

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**__Introduction:__** The basic pathophysiologic derangement of chronic kidney disease (CKD) begins with the loss of nephrons, leading to renal hemodynamic changes, eventually causing a reduced nephron count and renal hypoxia. The purpose of this study was to observe the renal oxygenation and renal hemodynamics of patients with CKD using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and intrarenal Doppler ultrasonography (IDU). **__Methods:__** The study enrolled 39 patients with stage 1–4 CKD and 19 healthy volunteers (HVs). Based on their estimated glomerular filtration rate (eGFR), CKD patients were divided into 2 subgroups: a mild renal impairment (MI) group and a moderate to severe renal impairment (MSI) group. We monitored the participants’ mean cortical T2\* (COT2\*) and mean medullary T2\* (MET2\*) values on BOLD-MRI, and measured the peak systolic velocities (PSVs), end-diastolic velocities (EDVs), renal resistive index (RI), and kidney length by IDU. We also recorded clinical indicators such as age, sex, body mass index (BMI), 24-h urinary protein (24-h Upr), serum creatinine (sCr), blood urea nitrogen (BUN), and eGFR. BOLD-MRI, IDU measurement

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Author

Jing Yang; Shuohui Yang; Yizeng Xu; Fang Lu; Lan You; Zheng He; Songhua Zhan; Chaoyang Ye; Mengxiao Liu; Caixia Fu; Chen Wang

Publisher

S. Karger AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)