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In Vitro and in Vivo Dissolution Behavior of a Dysprosium Lithium Borate Glass Designed for the Radiation Synovectomy Treatment of Rheumatoid Arthritis by Samuel D. Conzone; Roger F. Brown; Delbert E. Day; Gary J. Ehrhardt is a Medicine article available to read on EtoBox.
What is In Vitro and in Vivo Dissolution Behavior of a Dysprosium Lithium Borate Glass Designed for the Radiation Synovectomy Treatment of Rheumatoid Arthritis about?
## Abstract Dysprosium lithium borate (DyLB) glass microspheres were investigated for use in the radiation synovectomy treatment of rheumatoid arthritis. __In vitro__ testing focused on weight loss and cation dissolution from glass microspheres immersed in simulated synovial fluid (SSF) at 37°C for up to 64 days. __In vivo__ testing was performed by injecting glass microspheres into the stifle joints of Sprague‐Dawley rats and monitoring the biodegradability of the microspheres and the tissue response within the joints. The DyLB microspheres reacted nonuniformly in SSF with the majority of lithium and boron being dissolved, whereas nearly all of the dysprosium (>99.7%) remained in the reacted microspheres. Because the DyLB glasses released negligible amounts of dysprosium while reacting with SSF, they are considered safe for radiation synovectomy from the standpoint of unwanted radiation release from the joint capsule. Furthermore, the DyLB microspheres fragmented, degraded, and reacted with body fluids while in the joints of rats without histologic evidence of joint damage. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 260–268, 2002; DOI 10.1002/jbm.10047
Who reads In Vitro and in Vivo Dissolution Behavior of a Dysprosium Lithium Borate Glass Designed for the Radiation Synovectomy Treatment of Rheumatoid Arthritis?
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- Author
- Samuel D. Conzone; Roger F. Brown; Delbert E. Day; Gary J. Ehrhardt
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)