Can I read Metabolite Activation of Tumorigenic Signaling Pathways in the Tumor Microenvironment on EtoBox?
Metabolite Activation of Tumorigenic Signaling Pathways in the Tumor Microenvironment by Vivien Low; Zhongchi Li; John Blenis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Metabolite Activation of Tumorigenic Signaling Pathways in the Tumor Microenvironment about?
The role of metabolites exchanged in the tumor microenvironment is largely thought of as fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors. However, this view is shifting as metabolites are increasingly shown to function as signaling molecules that directly regulate oncogenic pathways. Combined with our growing understanding of the essential role of stromal cells, this shift has led to increased interest in how the collective and interconnected metabolome of the tumor microenvironment can drive malignant transformation, epithelial-to-mesenchymal transition, drug resistance, immune evasion, and metastasis. In this review, we discuss how metabolite exchange between tumors and various cell types in the tumor microenvironment—such as fibroblasts, adipocytes, and immune cells—can activate signaling pathways that drive cancer progression.
Who reads Metabolite Activation of Tumorigenic Signaling Pathways in the Tumor Microenvironment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Vivien Low; Zhongchi Li; John Blenis
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)