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Inflammation and Oxidative Stress in Adolescents With Type 1 Diabetes: The CARDEA Study by Morganne Masse; Natalia Silva Navarro; Vanessa Mcnealis; Soren Harnois-Leblanc; Jean-Claude Lavoie; Matthias G. Friedrich; Andraea Van Hulst; Anne Monique Nuyt; Jean-Luc Bigras; Tracie Barnett; Andrea Benedetti; Marie-Ève Mathieu; Vicky Drapeau; Mélanie Henderson is a Medicine article available to read on EtoBox.
What is Inflammation and Oxidative Stress in Adolescents With Type 1 Diabetes: The CARDEA Study about?
variant impairs insulin secretion when exposed to dietary carbohydrate stress but is protective in the context of traditional off-theland foods rich in fat and protein. Methods: CRISPR/Cas9 was used to knock-in the G>A.955 substitution into C57/BL6 mice. Mice were weaned onto (1) a high-fat, lowcarbohydrate (HFLC) diet reflecting off-the-land foods, or (2) a high-fat, high-carbohydrate (HFHC) diet reflecting present-day dietary patterns. Glucose tolerance was assessed prior to isolation of pancreatic islets to measure glucose-stimulated insulin secretion (GSIS). Results: An HFHC diet accelerated the development of glucose intolerance and impaired GSIS in G319S-expressing female mice between 12 and 24 weeks of age. Conversely, consuming an HFLC diet improved glucose tolerance in males and prevented GSIS impairments in females at 12 weeks of age. However, a long-term HFLC diet induced glucose intolerance and insulin hypersecretion across all genotypes and sexes. Conclusion: The short-term consumption of an HFLC diet appears to normalize insulin secretion and glucose tolerance in G319S carriers, although long-term intake is less favourable. Conversely, a presentday HFHC diet accelerat
Who reads Inflammation and Oxidative Stress in Adolescents With Type 1 Diabetes: The CARDEA Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Morganne Masse; Natalia Silva Navarro; Vanessa Mcnealis; Soren Harnois-Leblanc; Jean-Claude Lavoie; Matthias G. Friedrich; Andraea Van Hulst; Anne Monique Nuyt; Jean-Luc Bigras; Tracie Barnett; Andrea Benedetti; Marie-Ève Mathieu; Vicky Drapeau; Mélanie Henderson
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)