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Identification of small extracellular vesicle-linked miRNA specifically derived from intrafollicular cells in women with polycystic ovary syndrome by Chenchen Cui; Jie Wang; Xiao Han; Qian Wang; Shan Zhang; Shoujing Liang; Huan Li; Li Meng; Cuilian Zhang; Huanhuan Chen is a Medicine article available to read on EtoBox.
What is Identification of small extracellular vesicle-linked miRNA specifically derived from intrafollicular cells in women with polycystic ovary syndrome about?
## Research question: This study aimed to identify small extracellular vesicle (sev)-linked micrornas (mirna) specifically derived from intrafollicular cells in women with polycystic ovary syndrome (pcos) and to investigate their biological functions. ## Design: A total of 120 women were recruited from september 2017 to october 2018. to investigate mirna profiles in sev derived from follicular fluid and serum, 30 women with pcos and 30 without pcos were included for a mirna microarray containing probes interrogating 2549 human mirna. to study the expression levels of differentially expressed mirna, sev in follicular fluid obtained from another 30 pcos and 30 non-pcos patients were used for quantitative real-time polymerase chain reaction analysis. ## Results: A total of 281 sev-linked mirna specifically derived from intrafollicular cells were identified, 179 of which were expressed in both the pcos and non-pcos groups. twenty-six of the 179 intrafollicle-specific sev-linked mirna were predicted to target 1537 genes. functional analysis suggested that these genes were involved in pathways related to folliculogenesis, including the mapk, and pi3k-akt signalling pathways. quantitative
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- Author
- Chenchen Cui; Jie Wang; Xiao Han; Qian Wang; Shan Zhang; Shoujing Liang; Huan Li; Li Meng; Cuilian Zhang; Huanhuan Chen
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)