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Can I read Fibronectin-coating Enhances Attachment and Proliferation of Mesenchymal Stem Cells on a Polyurethane Meniscal Scaffold on EtoBox?

Fibronectin-coating Enhances Attachment and Proliferation of Mesenchymal Stem Cells on a Polyurethane Meniscal Scaffold by Arredondo, Raquel (author);Poggioli, Francesco (author);Martínez-Díaz, Santos (author);Piera-Trilla, María (author);Torres-Claramunt, Raúl (author);Tío, Laura (author);Monllau, Joan C. (author) is a Medicine article available to read on EtoBox.

What is Fibronectin-coating Enhances Attachment and Proliferation of Mesenchymal Stem Cells on a Polyurethane Meniscal Scaffold about?

## Introduction Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain of knee pain due to an overload in the ablated compartment. In these cases, implantation of tissue engineering scaffold could be indicated. Currently, two commercial scaffolds, based on collagen or polycaprolactone-polyurethane (PCL-PU), are available for meniscus scaffolding. In short term follow-up assessments, both showed clinical improvement and tissue formation. However, long-term studies carried out in PCL-PU showed that the new tissue decreased in volume and assumed an irregular shape. Moreover, in some cases, the scaffold was totally reabsorbed, without new tissue formation. Mesenchymal stem cells (MSCs) combined with scaffolds could represents a promising approach for treating meniscal defects because of their multipotency and self-renewal. In this work, we aimed to compare the behaviour of MSCs and chondrocytes on a PCL-PU scaffold __in vitro__. MSCs express integrins that binds to fibronectin (FN), so we also investigate the effect of a FN coating on the bioactivity of the scaffold. ## Methods We isolated rabbit bone marrow MSCs (rBM-MS

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Author
Arredondo, Raquel (author);Poggioli, Francesco (author);Martínez-Díaz, Santos (author);Piera-Trilla, María (author);Torres-Claramunt, Raúl (author);Tío, Laura (author);Monllau, Joan C. (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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