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This study investigated the use of magnetic drug targeting (MDT) to deliver the chemotherapy drug mitoxantrone coupled to iron oxide nanoparticles specifically to tumor tissue in rats. Rats were injected with rhabdomyosarcoma cancer cells to develop tumors and then received mitoxantrone-iron oxide either with or without application of an external magnet over the tumor. The concentrations of the drug in plasma and tumor tissue were measured and compared. MDT resulted in significantly higher concentrations of

Author

Ppa Gpat Amit

Language

EN