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Anomalous Advection-Diffusion Models for Avascular Tumour Growth by Sadhukhan, Sounak; Basu, S. K. is a scholarly article available to read on EtoBox.

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In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour spheroid. This understanding is likely to assist in the development of better diagnostics, improved therapies and prognostics. In biological systems, most of the diffusive and convective processes are through cellular membranes which are porous in nature. Due to its porous nature, diffusive processes in biological systems are heterogeneous. Fractional advection-diffusion equations are well suited to model heterogeneous biological systems; though most of the early studies did not use this fact. They modelled tumour growth with simple advection-diffusion equation or diffusion equation. We have developed two spherical models based on fractional advection-diffusion equations: one of fixed order and the other of variable order for avascular tumour. These two models are investigated from phenomenological view by measuring some parameters for characterizing avascular tumour growth over time. It is found that both the models offer realistic and insightful inform

Author

Sadhukhan, Sounak; Basu, S. K.

Published

2019

Language

EN