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A Switch in the Direction of the Effect of Insulin on the Partitioning of Hepatic Fatty Acids for the Formation of Secreted Triacylglycerol Occurs in Vivo , as Predicted from Studies with Perfused Livers by Susan M. Rennie; Byun‐Sung Park; Victor A. Zammit is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The direct effects of insulin on hepatic triacylglycerol secretion are important because they may determine the degree of postprandial hyperlipidaemia, a known risk factor for the development of atherosclerotic lesions. Previous work from this laboratory, conducted on isolated perfused rat livers [Zammit, V.A., Lankester, D.J., Brown, A.M. & Park, B.S. (1999) __Eur. J. Biochem.__**263**, 859–864], has indicated that the effect of insulin on hepatic triacylglycerol secretion is dependent on the prior physiological state of the donor animals. In this paper, we demonstrate that a switch in the direction of insulin action on hepatic partitioning of fatty acyl moieties towards triacylglycerol secretion also occurs __in vivo__ between the fed, normoinsulinaemic state and the fasted or severely insulin‐deficient states. The partitioning of fatty acids in the liver of awake, unstressed rats was studied using selective labelling of hepatic fatty acids during hyperinsulinaemic‐euglycaemic clamps achieved through the use of hepatocyte‐targeted liposome‐encapsulated insulin preparations. The data show that, whereas in the fed, normoinsulinaemic state, insulinization of the liver raises the pro

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Author

Susan M. Rennie; Byun‐Sung Park; Victor A. Zammit

Publisher

John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)