About this Chemistry article
Synthesis, characterisation and biological activity of three copper (II) complexes with a modified nitrogenous base: 5-formyluracil thiosemicarbazone by Marisa Belicchi Ferrari; Giovanna Gasparri Fava; Enrico Leporati; Giorgio Pelosi; Rossana Rossi; Pieralberto Tarasconi; Roberto Albertini; Antonio Bonati; Paolo Lunghi; Silvana Pinelli is a Chemistry article available to read on EtoBox.
Three Cu(II) co-ordination compounds with a novel ligand, 5-formyluracil thiosemicarbazone (H3ut), have been synthesised and characterised by single-crystal X-ray diffraction and subsequently tested in vitro on human leukemic cells. The crystal structures revealed, in all three cases, a square pyramidal co-ordination geometry of the copper atom with the ligand lying on the basal plane and behaving as an SNO terdentate ligand. These three compounds have been tested on human leukemic cell line K562 and CEM. In these experiments the complexes have demonstrated to inhibit cell growth and one of them to induce apoptosis. In the paper we also report the spectrophotometric characterization of the free ligand.
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- Author
- Marisa Belicchi Ferrari; Giovanna Gasparri Fava; Enrico Leporati; Giorgio Pelosi; Rossana Rossi; Pieralberto Tarasconi; Roberto Albertini; Antonio Bonati; Paolo Lunghi; Silvana Pinelli
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)
- Published
- 1998
- Language
- EN
- Field
- Chemistry (Physical Sciences)