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PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells by Jeewon Kim; Tomoyoshi Koyanagi; Daria Mochly-Rosen is a Medicine article available to read on EtoBox.

What is PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells about?

## Abstract ## BACKGROUND PKCδ is generally known as a pro‐apoptotic and anti‐proliferative enzyme in human prostate cancer cells. ## METHODS Here, we investigated the role of PKCδ on the growth of PC‐3 human prostate cancer cells in vivo and in vitro. ## RESULTS We found that sustained treatment with a specific PKCδ activator (ψδ receptor for active C kinase, ψδRACK) increased growth of PC‐3 xenografts. There was increased levels of HIF‐1α, vascular endothelial growth factor and CD31‐positive cells in PC‐3 xenografts, representative of increased tumor angiogenesis. Mechanistically, PKCδ activation increased the levels of reactive oxygen species (ROS) by binding to and phosphorylating NADPH oxidase, which induced its activity. Also, PKCδ‐induced activation of NADPH oxidase increased the level of HIF‐1α. ## CONCLUSIONS Our results using tumors from the PC‐3 xenograft model suggest that PKCδ activation increases angiogenic activity in androgen‐independent PC‐3 prostate cancer cells by increasing NADPH oxidase activity and HIF‐1α levels and thus may partly be responsible for increased angiogenesis in advanced prostate cancer. Prostate 71: 946–954, 2011. © 2010 Wiley‐Liss, Inc.

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Author

Jeewon Kim; Tomoyoshi Koyanagi; Daria Mochly-Rosen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2010

Language

EN

Field

Medicine (Health Sciences)