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Bone mineral density in Turner's syndrome—a longitudinal study by N. J. Shaw; V. K. Rehan; S. Husain; T. Marshall; C. S. Smith is a Medicine article available to read on EtoBox.

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## OBJECTIVE Osteoporosis is a recognized problem in adult women with Turner's syndrome, the aetiology of which is unclear. The aim of this study was to examine bone mineralization longitudinally in a group of girls with Turner's syndrome and to study the effect of different treatments on bone mineral density. ## DESIGN A prospective observational study. ## PATIENTS Eighteen girls with Turner's syndrome aged 4–17 years attending a paediatric endocrine clinic. ## MEASUREMENTS Bone mineral density of the lumbar spine was assessed using dual energy X‐ray absorptiometry at several time points over a 2.5‐year period. ## RESULTS Only one girl had evidence of a significant reduction in bone density when comparisons were made with control data related to body weight and pubertal status. No advantage was found for any form of treatment in optimizing bone mineralization. ## CONCLUSIONS As there is little evidence of reduced bone mineral density in girls with Turner's syndrome there is no justification for an early introduction of oestrogen replacement during the prepubertal years.

Who reads Bone mineral density in Turner's syndrome—a longitudinal study?

Author

N. J. Shaw; V. K. Rehan; S. Husain; T. Marshall; C. S. Smith

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1997

Language

EN

Field

Medicine (Health Sciences)