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TRPS1 outperforms GATA3 in pleural effusions with metastatic breast carcinoma versus mesothelioma by Farah Baban; Justin W. Koepplin; Muhammad Ahmad; Anna‐Lee Clarke‐Brodber; Melanie C. Bois; Christopher P. Hartley; Charles D. Sturgis is a Medicine article available to read on EtoBox.
What is TRPS1 outperforms GATA3 in pleural effusions with metastatic breast carcinoma versus mesothelioma about?
Introduction: In evaluating malignant pleural fluid cytology, metastatic adenocarcinomas and mesotheliomas are often differential diagnoses. GATA binding protein 3 (GATA3) has historically been used to confirm metastatic breast carcinomas; however, GATA3 has low specificity if mesothelioma is included in differential diagnoses.Trichorhinophalangeal syndrome type 1 (TRPS1) protein is expressed in all types of breast carcinomas, with reported high specificity and sensitivity. We investigated the performance of TRPS1 immunohistochemistry (IHC) and compared it to GATA3 in pleural fluids diagnosed with metastatic breast carcinoma and mesothelioma. Methods: Thirty-six consecutive ThinPrep pleural fluids and 4 pleural fine needle aspirations (FNAs) with diagnoses of metastatic breast carcinoma (21) and mesothelioma (19) were retrieved, and IHC with TRPS1 and GATA3 was performed on all. Immunoreactivity scores for TRPS1 were calculated by multiplying percentage of immunoreactive cells by staining intensity. Immunoreactivity scores were negative if 0 or 1, low positive if 2, intermediate positive if 3 or 4, or high positive if 6 or 9. Nuclear immunoreactivity of ≥10% with at least moderate
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- Author
- Farah Baban; Justin W. Koepplin; Muhammad Ahmad; Anna‐Lee Clarke‐Brodber; Melanie C. Bois; Christopher P. Hartley; Charles D. Sturgis
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)