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Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound by Lisa H. Treat; Nathan McDannold; Natalia Vykhodtseva; Yongzhi Zhang; Karen Tam; Kullervo Hynynen is a Medicine article available to read on EtoBox.

What is Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound about?

## Abstract The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood‐brain barrier (BBB). Although doxorubicin (DOX) has been named as a strong candidate for chemotherapy of the central nervous system (CNS), the BBB often prevents cytotoxic levels from being achieved. In this study, we demonstrate a noninvasive method for the targeted delivery of DOX through the BBB, such that drug levels shown to be therapeutic in human tumors are achieved in the normal rat brain. Using MRI‐guided focused ultrasound with preformed microbubbles (Optison) to locally disrupt the BBB and systemic administration of DOX, we achieved DOX concentrations of 886 ± 327 ng/g tissue in the brain with minimal tissue effects. Tissue DOX concentrations of up to 5,366 ± 659 ng/g tissue were achieved with higher Optison doses, but with more significant tissue damage. In contrast, DOX accumulation in nontargeted contralateral brain tissue remained significantly lower for all paired samples (__p__ < 0.001). These results suggest that targeted delivery by focused ultrasound may render DOX chemotherapy a viable treatmen

Who reads Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound?

Author

Lisa H. Treat; Nathan McDannold; Natalia Vykhodtseva; Yongzhi Zhang; Karen Tam; Kullervo Hynynen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2007

Language

EN

Field

Medicine (Health Sciences)