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Pharmacokinetics of Carboplatin After Intraperitoneal Administration by F. Elferink; W. J. F. van der Vijgh; I. Klein; W. W. ten Bokkel Huinink; R. Dubbelman; J. G. McVie is a Medicine article available to read on EtoBox.

What is Pharmacokinetics of Carboplatin After Intraperitoneal Administration about?

The pharmacokinetics of carboplatin, ultrafilterable platinum, and total platinum after intraperitoneal (i.p.) administration were studied in peritoneal fluid, plasma, red blood cells (RBCs), and urine during a phase-I trial in patients with minimal, residual ovarian cancer. Samples were collected from 7 patients who had received carboplatin (200-500 mg/m2) in 21 dialysis fluid. The fluid was withdrawn after a 4-h dwell. Platinum concentrations were measured by flameless atomic absorption spectrometry, and intact carboplatin was determined by HPLC with electrochemical detection. Peak concentrations of carboplatin in plasma were obtained 2 h after the end of instillation. The mean ratio of peak concentrations of carboplatin in instilled fluid and plasma was 24 +/- 11. The peritoneal clearance of carboplatin was 8 +/- 3 ml/min, which was 12 times less than the plasma clearance (93 +/- 32 ml/min). Due to this clearance ratio, the AUCs for the peritoneal cavity were about 10 times higher than those for plasma. On average, 34% +/- 14% of the dose was still present in the instillation fluid that had been withdrawn after a dwell time of 4 h. In plasma, the mean value of AUC/Dnet (Dnet = D

Who reads Pharmacokinetics of Carboplatin After Intraperitoneal Administration?

Author

F. Elferink; W. J. F. van der Vijgh; I. Klein; W. W. ten Bokkel Huinink; R. Dubbelman; J. G. McVie

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0344-5704)

Published

1987

Language

EN

Field

Medicine (Health Sciences)