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Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normoglycemic and prediabetic Japanese subjects by Masanori Shimodaira; Tomohiro Niwa; Koji Nakajima; Mutsuhiro Kobayashi; Norinao Hanyu; Tomohiro Nakayama is a Medicine article available to read on EtoBox.

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## Abstract ## Aims/Introduction Mean platelet volume (MPV) reflects platelet activity, and high MPV is associated with thrombogenic activation and increased cardiovascular disease risk. Although a positive correlation between MPV and fasting plasma glucose (FPG) levels has been reported, the correlation between MPV and postprandial glucose levels remains unclear. The purpose of the present study was to evaluate the correlation between MPV and postprandial glucose levels in prediabetic and normoglycemic participants. ## Materials and Methods We evaluated 1,080 Japanese participants who underwent the 75‐g oral glucose tolerance test (OGTT). Based on these results, the participants were divided into three groups: normal glucose tolerance group (NGT; __n__ = 582), impaired fasting glucose group (IFG; __n__ = 205) and impaired glucose tolerance group (IGT; __n__ = 252). The relationship between MPV, FPG, and postchallenge glucose levels after 1 h (1 h‐PG) and 2 h (2 h‐PG) were analyzed. ## Results Bivariate correlation analyses showed a significant positive correlation between MPV and both FPG and 1 h‐PG levels in the NGT group, as well as between MPV and 2 h‐PG, total cholesterol, and

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Author

Masanori Shimodaira; Tomohiro Niwa; Koji Nakajima; Mutsuhiro Kobayashi; Norinao Hanyu; Tomohiro Nakayama

Publisher

Wiley

Published

2013

Language

EN

Field

Medicine (Health Sciences)