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Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy by Yoon Kyung Shin; So Young Jang; Hyun Kyoung Lee; Junyang Jung; Duk Joon Suh; Su-Yeong Seo; Hwan Tae Park is a Neuroscience article available to read on EtoBox.
What is Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy about?
## Abstract Bortezomib, a proteasome inhibitor, has been considered as a promising anticancer drug in the treatment of recurrent multiple myeloma and some solid tumors. The bortezomib‐induced peripheral neuropathy (BIPN) is a prominent cause of dose‐limiting toxicities after bortezomib treatment. In this study, we found that BIPN in a mouse model is characterized by acute but transient endoplasmic reticulum (ER) damages to Schwann cells. These damaged Schwann cells exhibit abnormal outcomes from healing processes such as the myelination of Remak bundles. A morphometric analysis of polymyelinated Remak bundles revealed that the pathological myelination was not related to the axonal parameters that regulate the normal myelination process during development. In addition, demyelinating macrophages were focally infiltrated within endoneurium of the sciatic nerve. To identify the mechanism underlying these pathologies, we applied a gene microarray analysis to bortezomib‐treated primary Schwann cells and verified the changes of several gene expression in bortezomib‐treated sciatic nerves. The analysis showed that bortezomib‐induced ER stress was accompanied by the activation of several pr
Who reads Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yoon Kyung Shin; So Young Jang; Hyun Kyoung Lee; Junyang Jung; Duk Joon Suh; Su-Yeong Seo; Hwan Tae Park
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)