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Can I read CFTR gene mutation spectrum among 735 Iranian patients with cystic fibrosis: A comprehensive systematic review on EtoBox?
CFTR gene mutation spectrum among 735 Iranian patients with cystic fibrosis: A comprehensive systematic review by Reza Alibakhshi; Aboozar Mohammadi; Sahand Khamooshian; Mohsen Kazeminia; Keivan Moradi is a Medicine article available to read on EtoBox.
What is CFTR gene mutation spectrum among 735 Iranian patients with cystic fibrosis: A comprehensive systematic review about?
In this study, the spectrum and frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations previously reported among Iranian cystic fibrosis (CF) patients have been reviewed and discussed. Using the keywords of Cystic Fibrosis, CF, CFTR, and Iran, along with their Persian equivalents, a comprehensive search was performed on the online databases. After applying the inclusion and exclusion criteria, 16 articles with an overall sample of 735 Iranian patients with CF, were included in this systematic review. A total of 101 different CFTR gene variants had been reported. The mutation of p.Phe508del (c.1521\_1523delCTT) (21.22%) was the most frequent one among Iranian patients with CF. In conclusion, due to the fact that in many provinces of Iran no specific study has been done so far, it seems that the CFTR gene mutation spectrum in patients with CF from Iran is much wider.
Who reads CFTR gene mutation spectrum among 735 Iranian patients with cystic fibrosis: A comprehensive systematic review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Reza Alibakhshi; Aboozar Mohammadi; Sahand Khamooshian; Mohsen Kazeminia; Keivan Moradi
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)