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Water Maze Experience and Prenatal Choline Supplementation Differentially Promote Long‐term Hippocampal Recovery from Seizures in Adulthood by Sarah J.E. Wong‐Goodrich; Melissa J. Glenn; Tiffany J. Mellott; Yi B. Liu; Jan K. Blusztajn; Christina L. Williams is a Neuroscience article available to read on EtoBox.

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## Abstract Status epilepticus (SE) in adulthood dramatically alters the hippocampus and produces spatial learning and memory deficits. Some factors, like environmental enrichment and exercise, may promote functional recovery from SE. Prenatal choline supplementation (SUP) also protects against spatial memory deficits observed shortly after SE in adulthood, and we have previously reported that SUP attenuates the neuropathological response to SE in the adult hippocampus just 16 days after SE. It is unknown whether SUP can ameliorate longer‐term cognitive and neuropathological consequences of SE, whether repeatedly engaging the injured hippocampus in a cognitive task might facilitate recovery from SE, and whether our prophylactic prenatal dietary treatment would enable the injured hippocampus to more effectively benefit from cognitive rehabilitation. To address these issues, adult offspring from rat dams that received either a control (CON) or SUP diet on embryonic days 12–17 first received training on a place learning water maze task (WM) and were then administered saline or kainic acid (KA) to induce SE. Rats then either remained in their home cage, or received three additional WM

Who reads Water Maze Experience and Prenatal Choline Supplementation Differentially Promote Long‐term Hippocampal Recovery from Seizures in Adulthood?

Author

Sarah J.E. Wong‐Goodrich; Melissa J. Glenn; Tiffany J. Mellott; Yi B. Liu; Jan K. Blusztajn; Christina L. Williams

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2010

Language

EN

Field

Neuroscience (Life Sciences)