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(+)-12α-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens by Pei-Lan Ding; Zhi-Xin Liao; Hai Huang; Pei Zhou; Dao-Feng Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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+)-12a-Hydroxysophocarpine (8), a new quinolizidine alkaloid was isolated from the roots of Sophora flavescens, together with 10 known quinolizidine alkaloids, (+)-oxymatrine (1), (+)-matrine (2), (+)-9a-hydroxymatrine (3), (+)-allomatrine ( 4), (+)-oxysophocarpine ( 5), (À)-sophocarpine ( 6), (À)-9a-hydroxysophocarpine ( 7), (+)-lehmannine ( 9), (À)-13,14-dehydrosophoridine (10), and (À)-anagyrine (11). Their structures were elucidated by spectroscopic methods, and the stereochemistry of 8 was confirmed by X-ray analysis. These alkaloids were tested for anti-hepatitis B virus (HBV) activity in vitro, compounds 5, 6, 9, and 10 showed significant anti-HBV activity with inhibitory potency against HBsAg secretion at 48.3-79.3% and that against HBeAg secretion at 24.6-34.6%.

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Author

Pei-Lan Ding; Zhi-Xin Liao; Hai Huang; Pei Zhou; Dao-Feng Chen

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)