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Babao Dan Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/β-Catenin Pathway by Meng-xuan Gui; Bin Huang; Jun Peng; Xi Chen; Ragunath Muthu; Ying Gao; Rui-guo Wang; Jiu-mao Lin is a Medicine article available to read on EtoBox.

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## Objective: To evaluate the protective function of babao dan (bbd) on 5-flurouracil (5-fu)-induced intestinal mucositis (im) and uncover the underlying mechanism. ## Methods: A total of 18 male mice were randomly divided into 3 groups by a random number table, including control, 5-fu and 5-fu combined bbd groups, 6 mice in each group. a single intraperitoneal injection of 5-fu (150 mg/kg) was performed in 5-fu and 5-fu combined bbd groups on day 0. mice in 5-fu combined bbd group were gavaged with bbd (250 mg/kg) daily from day 1 to 6. mice in the control group were gavaged with saline solution for 6 days. the body weight and diarrhea index of mice were recorded daily. on the 7th day, the blood from the heart of mice was collected to analyze the proportional changes of immunological cells, and the mice were subsequently euthanized by mild anesthesia with 2% pentobarbital sodium. colorectal lengths and villus heights were measured. intestinal-cellular apoptosis and proliferation were evaluated by tunel assay and immunohistochemical staining of proliferating cell nuclear antigen, respectively. immunohistochemistry and western blot were performed to investigate the expressions of co

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Author

Meng-xuan Gui; Bin Huang; Jun Peng; Xi Chen; Ragunath Muthu; Ying Gao; Rui-guo Wang; Jiu-mao Lin

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)