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Morphological and Immunophenotypical Analysis of the Spindle Cell Component in Adenomyomatous Hyperplasia of the Gallbladder by Kritika Krishnamurthy; Christopher A. Febres-Aldana; Steven Melnick; Vathany Sriganeshan; Robert J. Poppiti is a Medicine article available to read on EtoBox.

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## Summary ## Background Adenomyomatous hyperplasia (AMH) of the gallbladder, reported in 1-8.7% of cholecystectomies, consists of cystically dilated sinuses/glands with a surrounding spindle cell proliferation which is thought to be composed of smooth muscle cells. Myofibroblasts are contractile cells that secrete a variety of biochemical modulators causing a “field-effect”. Myofibroblasts can be immunohistochemically distinguished from smooth muscle cells by their desmin negativity. ## Methods Eighteen cases of AMH and five cases each of chronic follicular cholecystitis, chronic cholecystitis, gallbladder carcinoma and 10 colonic diverticular disease were stained with actin and desmin. The percentage of myofibroblasts was estimated by the difference between actin and desmin staining in the same field. Statistical anlysis was performed using SPSS 22.0. ## Results The percentage of actin staining was significantly higher in AMH and gallbladder carcinoma compared to chronic follicular and chronic cholecystitis (p = 0.04). The percentage of desmin staining did not show any significant difference between the four groups. The estimated myofibroblastic population was significantly highe

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Author

Kritika Krishnamurthy; Christopher A. Febres-Aldana; Steven Melnick; Vathany Sriganeshan; Robert J. Poppiti

Publisher

Siapec Servizi Srl

Published

2021

Field

Medicine (Health Sciences)