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The Association between the Alpha-Fibrinogen Thr312Ala (rs6050) Polymorphism and Risk of Venous Thromboembolism Among Enrollees in the Gate Study by Amanda B Payne; Christine De Staercke; Joshua W Francis; Harland D. Austin; Kavita N Patel; Christopher J. Bean; W. Craig Hooper is a Medicine article available to read on EtoBox.
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## Abstract Introduction: The final events of the activated clotting cascade include the conversion of fibrinogen to fibrin and stabilization of the growing fibrin clot by factor XIII (FXIII). A missense variant in the alpha chain of fibrinogen, α-fibrinogen (FGA) Thr312Ala (rs6050, NM\_000508.3:c.991A>G, NP\_000499.1:p.[Thr331Ala]), has been previously shown to interfere with FXIII-dependent cross-linking, leading to stiffer blood clots. It is believed this pathophysiology underlies the increased risk of venous thromboembolism (VTE) associated with the variant. The Thr312Ala variant has been shown to be significantly associated with VTE among White, Non-Hispanic populations. The only investigation of the variant in a Black population (Rasmussen-Torvik et al 2007) found no significant relationship between Thr312Ala and VTE, but the authors cite the relatively small number of participants included in the analysis as a possible reason for a null finding. We investigated the association between FGA Thr312Ala and VTE in a case-control study enrolling a relatively large racially diverse study population. Methods: Conditional logistic regression was used to assess the association between
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- Author
- Amanda B Payne; Christine De Staercke; Joshua W Francis; Harland D. Austin; Kavita N Patel; Christopher J. Bean; W. Craig Hooper
- Publisher
- American Society of Hematology
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)