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Can I read Capturing the environment of the Clostridioides difficile infection cycle on EtoBox?
Capturing the environment of the Clostridioides difficile infection cycle by Matthew K. Schnizlein; Vincent B. Young is a Medicine article available to read on EtoBox.
What is Capturing the environment of the Clostridioides difficile infection cycle about?
Clostridioides difficile (formerly Clostridium difficile) is a Gram-positive, spore-forming bacterium that colonizes individuals whose microbiota is perturbed in structure and function such that colonization resistance to non-indigenous microorganisms is lost [1][2][3] . Understanding the latest advances in C. difficile physiology and what constitutes colonization resistance is required before we can develop precision medicine-based treatments for C. difficile infection (CDI). C. difficile can be successful as a pathogen owing to its ability to adapt to unique environments, particularly those created by antibiotic disruption in the gut 4 . This adaptability is largely due to the diversity of its genome 5 . The genomic and strain diversity of C. difficile, which is well reviewed elsewhere [5][6][7] , is distributed across six phylogenetic clades. Only a small percentage of its genes are present across all sequenced isolates (~16-19%), a number likely to go down as more strains are sequenced 8,9 . This finding reflects the evolution of C. difficile to fit unique environmental circumstances. CDI is usually acquired within clinical settings, in part due to an increased prevalence of C.
Who reads Capturing the environment of the Clostridioides difficile infection cycle?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Matthew K. Schnizlein; Vincent B. Young
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)