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Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form by Carlos Cativiela; Maria D. Diaz-de-Villegas; José A. Galvez is a Chemistry article available to read on EtoBox.

What is Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form about?

A new strategy for the preparation of both enantiomers of 2-amino-2methylbutanoic acid (iva) based on diastereoselective aikyiation of (lS,2R,4R)-1 Odioyoiohexylsulfamoylisobornyl P-cyanoesters and the corresponding degradation process is described. Non-proteinogenic, unnatural a-aminoacids have attracted the attention of numerous researchers1 in connection with the design and synthesis of enzyme inhibitors, as potential constituents of pharmaceuticals, as optically active starting materials for a variety of synthetic applications, and for the study of enzymatic reaction mechanisms. In particular, a,a-disubstituted a-amino acids have been the subject of considerable research in the last few years. A large number of these studies have focused on chiral (-)-(ZR)-2-aminoQ-methylbutanoic acid (D-iva),\*

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Author

Carlos Cativiela; Maria D. Diaz-de-Villegas; José A. Galvez

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0957-4166)

Published

1993

Language

EN

Field

Chemistry (Physical Sciences)