Can I read Colorectal Cancer Stem Cells on EtoBox?
Colorectal Cancer Stem Cells by Aristides G. Vaiopoulos; Ioannis D. Kostakis; Michael Koutsilieris; Athanasios G. Papavassiliou is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Colorectal Cancer Stem Cells about?
Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic aberrations. There are several issues concerning colorectal carcinogenesis that remain unanswered, such as the cell of origin and the type of cells that propagate the tumor after its initiation. There are two models of carcinogenesis: the stochastic and the cancer stem cell (CSC) model. According to the stochastic model, any kind of cell is capable of initiating and promoting cancer development, whereas the CSC model suggests that tumors are hierarchically organized and only CSCs possess cancer-promoting potential. Moreover, various molecular pathways, such as Wingless/Int (Wnt) and Notch, as well as the complex crosstalk network between microenvironment and CSCs, are involved in CRC. Identification of CSCs remains controversial due to the lack of widely accepted specific molecular markers. CSCs are responsible for tumor relapse, because conventional drugs fail to eliminate the CSC reservoir. Therefore, the design of CSC-targeted interventions is a rational target, which will enhance responsiveness to traditional
Who reads Colorectal Cancer Stem Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Aristides G. Vaiopoulos; Ioannis D. Kostakis; Michael Koutsilieris; Athanasios G. Papavassiliou
- Publisher
- Oxford University Press (OUP)
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)