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P058 Intracellular ROS in bone marrow cells in myelodysplastic syndrome: technical and methodological considerations by L. Chan; R. Buckstein; M. Reis; A. Chesney; A. Lam; M. Cheung; E. Piliotis; L. Gu; R. Wells is a Medicine article available to read on EtoBox.
What is P058 Intracellular ROS in bone marrow cells in myelodysplastic syndrome: technical and methodological considerations about?
Myelodysplastic syndromes (MDS) in radiation exposed are characterized by a combination of ineffective hematopoiesis with late radiation post-effects. Increase of apoptosis and changes of telomere length were demonstrated in irradiation experiments and exposed humans indicating possible modifying role in myelodysplasia pathways after irradiation. Patients and Methods: Peripheral blood samples were studied in 23 patients MDS-RA (17 Chernobyl cleanup workers, mean dose 0.42 Sv; 6 non-exposed) and comparison groups: acute myeloid leukemia (n = 4), Chernobyl cleanup workers without MDS (n = 10) 20-22 years after exposure, nuclear industry staff (n = 10, mean dose 6.3±0.37 mSv), and nonexposed controls (n = 10). Early and late apoptosis was detected in Annexin-V test, telomere length -by PNA flow-FISH assay. Results: MDS-RA samples have demonstrated high levels of granulocyte and lymphocyte apoptosis and significantly lower relative telomere length (RTL) index in comparison with healthy controls. Comparison of MDS-RA in radiation exposed with other irradiated groups has shown the absence of differences in spontaneous level of early apoptosis while the late apoptotic cells fraction (Anne
Who reads P058 Intracellular ROS in bone marrow cells in myelodysplastic syndrome: technical and methodological considerations?
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- Author
- L. Chan; R. Buckstein; M. Reis; A. Chesney; A. Lam; M. Cheung; E. Piliotis; L. Gu; R. Wells
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)