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Comparative Metagenome-Assembled Genome Analysis of “Candidatus Lachnocurva vaginae”, Formerly Known as Bacterial Vaginosis-Associated Bacterium−1 (BVAB1) by Holm, Johanna B.; France, Michael T.; Ma, Bing; McComb, Elias; Robinson, Courtney K.; Mehta, Aditya; Tallon, Luke J.; Brotman, Rebecca M.; Ravel, Jacques is a Medicine article available to read on EtoBox.

What is Comparative Metagenome-Assembled Genome Analysis of “Candidatus Lachnocurva vaginae”, Formerly Known as Bacterial Vaginosis-Associated Bacterium−1 (BVAB1) about?

Bacterial vaginosis-associated bacterium 1 (BVAB1) is an as-yet uncultured bacterial species found in the human vagina that belongs to the family __Lachnospiraceae__ within the order __Clostridiales__. As its name suggests, this bacterium is often associated with bacterial vaginosis (BV), a common vaginal disorder that has been shown to increase a woman's risk for HIV, __Chlamydia trachomatis__, and __Neisseria gonorrhoeae__ infections as well as preterm birth. BVAB1 has been further associated with the persistence of BV following metronidazole treatment, increased vaginal inflammation, and adverse obstetrics outcomes. There is no available complete genome sequence of BVAB1, which has made it difficult to mechanistically understand its role in disease. We present here a circularized metagenome-assembled genome (cMAG) of BVAB1 as well as a comparative analysis including an additional six metagenome-assembled genomes (MAGs) of this species. These sequences were derived from cervicovaginal samples of seven separate women. The cMAG was obtained from a metagenome sequenced with long-read technology on a PacBio Sequel II instrument while the others were derived from metagenomes sequenced

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Author

Holm, Johanna B.; France, Michael T.; Ma, Bing; McComb, Elias; Robinson, Courtney K.; Mehta, Aditya; Tallon, Luke J.; Brotman, Rebecca M.; Ravel, Jacques

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2235-2988)

Published

2020

Language

EN

Field

Medicine (Health Sciences)