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Neuroscience Bulletin,Received: 7 September 2024 / Accepted: 6 November 2024 / Published online: 20 January 2025© Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2025Chronic pain, characterized by pain lasting for more than potential mechanisms, and future directions for treating three months, is a debilitating condition frequently caused chronic pain.by conditions such as fbromyalgia, arthritis, neuropathy, and The therapeutic potential of psychedelics in managing migraine [1–3]. Beyond its physical implications, chronic various types of chronic pain is an emerging area of interpain signifcantly impacts mental health, frequently leading est within the medical community (Table 1). Psilocybin has to conditions like depression and anxiety [4]. Traditional shown promise in treating chronic pain conditions such as treatments, including opioids and nonsteroidal anti-infammigraines and cluster headaches. Studies have shown that matory drugs, often prove inadequate, leaving many suferpsilocybin can signifcantly reduce the frequency and severers in a state of persistent discomfort and diminished quality ity of cluster headache attacks and

Author

Cong Lin & Xue Wang & Xiaohui Wang

Publisher

Springer

Published

2025

Language

EN