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Persistence of DNA Sequences of BK Virus and JC Virus in Normal Human Tissues and in Diseased Tissues by P. M. Chesters; J. Heritage; D. J. McCance is a Medicine article available to read on EtoBox.

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Available evidence suggests that BK virus (BKV) and lC virus (lCV) persist in the kidneys of healthy individuals after primary infection and may reactivate when the host's immune response is impaired. Data supporting this hypothesis are presented. A previous study had shown BKV to be present in the kidneys of eight (57%) of 14 subjects. In the present study, which extended the investigation to a total of 30 subjects, BKV DNA was found in the renal tissues of 10 (33070) subjects, and lCV DNA was found in the renal tissues of three ( 10070) subjects. The viral DNA detected appeared not to be integrated with host DNA and to be isolated in foci. Investigation of normal and diseased brain tissue, including tissue from six subjects with multiple sclerosis, failed to reveal the presence of either leV DNA or BKV DNA. BK virus (BKV), a human polyomavirus, was first isolated from the urine of a patient who had received a kidney and ureter transplant four months previously [1]. JC virus (J CV) was first isolated from a patient with the demyelinating disease progressive multi focal leukoencephalopathy [2]. Infection with these viruses appears to be widespread: serologic studies have shown that

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Author

P. M. Chesters; J. Heritage; D. J. McCance

Published

1983

Language

EN

Field

Medicine (Health Sciences)