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A cluster of Candida krusei infections in a haematological unit by Timo Hautala; Irma Ikäheimo; Heidi Husu; Marjaana Säily; Timo Siitonen; Pirjo Koistinen; Jaana Vuopio-Varkila; Markku Koskela; Pekka Kujala is a Medicine article available to read on EtoBox.
What is A cluster of Candida krusei infections in a haematological unit about?
## Background __Candida krusei__ infections are associated with high mortality. In order to explore ways to prevent these infections, we investigated potential routes for nosocomial spread and possible clonality of __C. krusei__ in a haematological unit which had experienced an unusually high incidence of cases. ## Methods We searched for __C. krusei__ contamination of the hospital environment and determined the level of colonization in patients and health care workers. We also analyzed the possible association between exposure to prophylactic antifungals or chemotherapeutic agents and occurrence of __C. krusei__. The __C. krusei__ isolates found were genotyped by pulsed-field electrophoresis method in order to determine possible relatedness of the cases. ## Results Twelve patients with invasive __C. krusei__ infection and ten patients with potentially significant infection or mucosal colonization were documented within nine months. We were unable to identify any exogenic source of infection or colonization. Genetic analysis of the isolates showed little evidence of clonal transmission of __C. krusei__ strains between the patients. Instead, each patient was colonized or infected by
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- Author
- Timo Hautala; Irma Ikäheimo; Heidi Husu; Marjaana Säily; Timo Siitonen; Pirjo Koistinen; Jaana Vuopio-Varkila; Markku Koskela; Pekka Kujala
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)