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Long-term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero by Benjamin J. S. al-Haddad; Bo Jacobsson; Shilpi Chabra; Dominika Modzelewska; Erin M. Olson; Raphael Bernier; Daniel A. Enquobahrie; Henrik Hagberg; Svante Östling; Lakshmi Rajagopal; Kristina M. Adams Waldorf; Verena Sengpiel is a Medicine article available to read on EtoBox.
What is Long-term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero about?
## Importance: The developmental origins of mental illness are incompletely understood. although the development of autism and schizophrenia are linked to infections during fetal life, it is unknown whether more common psychiatric conditions such as depression might begin in utero. ## Objective: To estimate the risk of psychopathologic conditions imparted from fetal exposure to any maternal infection while hospitalized during pregnancy. ## Design, setting, and participants: A total of 1 791 520 swedish children born between january 1, 1973, and december 31, 2014, were observed for up to 41 years using linked population-based registries. children were excluded if they were born too late to contribute person-time, died before being at risk for the outcome, or were missing particular model data. infection and psychiatric diagnoses were derived using codes from hospitalizations. directed acyclic graphs were developed from a systematic literature review to determine cox proportional hazards regression models for risk of psychopathologic conditions in the children. results were evaluated using probabilistic and simple bias analyses. statistical analysis was conducted from february 10 to
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Benjamin J. S. al-Haddad; Bo Jacobsson; Shilpi Chabra; Dominika Modzelewska; Erin M. Olson; Raphael Bernier; Daniel A. Enquobahrie; Henrik Hagberg; Svante Östling; Lakshmi Rajagopal; Kristina M. Adams Waldorf; Verena Sengpiel
- Publisher
- American Medical Association (AMA)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Social Sciences)